BDBM364502 US9862707, Example 77

SMILES Cc1ccccc1-n1nc2cc(ccc2c1NC(=O)c1cc(-c2ccn(C)n2)c(cc1F)C(F)(F)F)C(N)=O

InChI Key InChIKey=JQEZBHLEXLABRF-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364502   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364502(US9862707, Example 77)
Affinity DataIC50: 1.30nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent