BDBM364524 N-(7-((2,5-dioxoimidazolidin-1- yl)methyl)-2-phenyl-2H- pyrazolo[4,3-b]pyridin-3-yl)-2- fluoro-5-(1-methyl-1H-pyrazol-3- yl)-4-(trifluoromethyl)benzamide::US9862707, Example 99

SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2n(nc3c(CN4C(=O)CNC4=O)ccnc23)-c2ccccc2)c(F)cc1C(F)(F)F

InChI Key InChIKey=GXHGCXDPSFWOQQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 364524   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM364524(US9862707, Example 99 | N-(7-((2,5-dioxoimidazolid...)
Affinity DataIC50: 0.880nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2019
Entry Details
US Patent