BDBM365034 4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine::US10278975, Compound I-9 S::US11376260, Example I-9S::US9867833, Compound I-9(S)

SMILES CN1C[C@H](Cc2ccccc2)c2nnc3cc(cc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=SWCBDPINUHFPBA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 365034   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365034(4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- te...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2020
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365034(4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- te...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 6(Human)
Genentech

US Patent
LigandPNGBDBM365034(4-(3-benzyl-5-methyl-4,5- dihydro-3H-1,2,2a1,5- te...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
Go to US Patent