BDBM365201 (S)-2-[4-(2-((1-methyl-1H- pyrazol-5- yl)amino)pyrimidin-4-yl)]- 8,9-dihydro-7H-6-oxa- 1,2,2a1-triazabenzo[cd] azulen-9-yl)butanenitrile::US10517878, Compound I-105::US10842799, I-105::US9867833, Compound I-105(S)

SMILES CCC(C#N)C1CCOc2cc(cc3nnc1n23)-c1ccnc(Nc2ccnn2C)n1

InChI Key InChIKey=CYZNMCWEXWUOBS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 365201   

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365201(US9867833, Compound I-105(S) | (S)-2-[4-(2-((1-met...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/6/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365201(US9867833, Compound I-105(S) | (S)-2-[4-(2-((1-met...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365201(US9867833, Compound I-105(S) | (S)-2-[4-(2-((1-met...)
Affinity DataIC50: 0.0200nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetMitogen-activated protein kinase 1(Human)
Genentech

US Patent
LigandPNGBDBM365201(US9867833, Compound I-105(S) | (S)-2-[4-(2-((1-met...)
Affinity DataIC50: 0.0820nMAssay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an n-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2019
Entry Details
US Patent