BDBM366680 4-[[8-[4-(4- chlorophenyl)-4- (hydroxymethyl)-1- piperidyl]- [1,2,4]triazolo[1,5- a]pyridin-2-yl]amino]- N-[2-[(2S,6S)-2,6- dimethylmorpholin-4- yl]ethyl]benzamide::US9873709, Example 1-277

SMILES C[C@H]1CN(CCNC(=O)c2ccc(Nc3nc4c(cccn4n3)N3CCC(CO)(CC3)c3ccc(Cl)cc3)cc2)C[C@H](C)O1

InChI Key InChIKey=HMPBTTNGSDGQNT-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 366680   

TargetTyrosine-protein kinase JAK2(Human)
Genentech

US Patent
LigandPNGBDBM366680(US9873709, Example 1-277 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.240nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent

TargetTyrosine-protein kinase JAK1(Human)
Genentech

US Patent
LigandPNGBDBM366680(US9873709, Example 1-277 | 4-[[8-[4-(4- chlorophen...)
Affinity DataKi:  0.390nMAssay Description:The activity of the isolated recombinant JAK1 and JAK2 kinase domain was measured by monitoring phosphorylation of a peptide derived from JAK3 (Val-A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2019
Entry Details
US Patent