BDBM367976 2-((2-sulfamoyl-3-(1H- tetrazol-5-yl)-4-(3- (trifluoromethyl)-1H- indazol-5- yl)phenyl)sulfonyl) ethanaminium 2,2,2- trifluoroacetate::US10227331, Example 163

SMILES NCCS(=O)(=O)c1ccc(-c2ccc3[nH]nc(c3c2)C(F)(F)F)c(-c2nnn[nH]2)c1S(N)(=O)=O

InChI Key InChIKey=YGJLBWBFHGZBGM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 367976   

TargetMetallo-beta-lactamase type 2(Serratia marcescens)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367976(US10227331, Example 163 | 2-((2-sulfamoyl-3-(1H- t...)
Affinity DataIC50: 1.22nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetMetallo-beta-lactamase type 2(Pseudomonas aeruginosa (g-Proteobacteria))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367976(US10227331, Example 163 | 2-((2-sulfamoyl-3-(1H- t...)
Affinity DataIC50: 0.980nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent

TargetVIM-1 protein(Pseudomonas aeruginosa)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM367976(US10227331, Example 163 | 2-((2-sulfamoyl-3-(1H- t...)
Affinity DataIC50: 0.120nMAssay Description:The Class B enzyme activities were measured in the presence of the test inhibitor in a fluorescence assay against a commercially available substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
Go to US Patent