BDBM368373 US10227342, Example 9

SMILES CCOC(=O)c1cnc(Nc2cc(NC(=O)C=C)c(cc2OC)N(C)CCN(C)C)nc1-c1cn(C)c2ccccc12

InChI Key InChIKey=FCZMHSXKERLEIN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 368373   

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50: 19nMAssay Description:Inhibition of EGR-induced EGFR phosphorylation in human A549 cells pretreated for 2 hrs followed by EGF stimulation by immune assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
TargetEpidermal growth factor receptor [T790M,L858R](Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR L858R and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine pro-B cell l...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M](Human)
Ariad Pharmaceuticals

US Patent
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 19 deletion and T790M concurrent mutations can be assessed using Ba/F3 cells, a murine p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting EGFR exon 20 insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line, whic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Ariad Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM368373(US10227342, Example 9)
Affinity DataIC50: 100nMAssay Description:A compound's ability in selectively inhibiting Her2 exon 20 YVMA insertion mutations can be assessed using Ba/F3 cells, a murine pro-B cell line,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent