BDBM368485 N-(1H-pyrazolo[3,4-b] pyrazin-3-yl)-1- (tetrahydropyran-2- ylmethoxy) isoquinolin-6-amine::US10227343, Example 20::US10968227, Compound 57

SMILES C(Oc1nccc2cc(Nc3n[nH]c4nccnc34)ccc12)C1CCCCO1

InChI Key InChIKey=QTMISHUPJBRYMM-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368485   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368485(N-(1H-pyrazolo[3,4-b] pyrazin-3-yl)-1- (tetrahydro...)
Affinity DataEC50:  69.7nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368485(N-(1H-pyrazolo[3,4-b] pyrazin-3-yl)-1- (tetrahydro...)
Affinity DataEC50:  70nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent