BDBM368511 1-(1-methyl-3- (trifluoromethyl)-1H- pyrazol-5-yl)-N- (1H-pyrazolo[4,3-b] pyridin-3-yl)isoquinolin- 6-amine::US10227343, Example 43

SMILES Cn1nc(cc1-c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12)C(F)(F)F

InChI Key InChIKey=LEKGTHUFCFCMSD-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368511   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368511(1-(1-methyl-3- (trifluoromethyl)-1H- pyrazol-5-yl)...)
Affinity DataEC50:  132nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368511(1-(1-methyl-3- (trifluoromethyl)-1H- pyrazol-5-yl)...)
Affinity DataEC50:  132nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed