BDBM368516 1-(3,3-difluoroazetidin- 1-yl)-N-(1H- pyrazolin[4,3-b] pyridin-3-yl)isoquinolin- 6-amine::US10227343, Example 130::US10227343, Example 48

SMILES FC1(F)CN(C1)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key InChIKey=QREJBZCECYHHBM-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 368516   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368516(1-(3,3-difluoroazetidin- 1-yl)-N-(1H- pyrazolin[4,...)
Affinity DataEC50:  51.6nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368516(1-(3,3-difluoroazetidin- 1-yl)-N-(1H- pyrazolin[4,...)
Affinity DataEC50:  52nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent