BDBM368520 N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluoromethyl) isoquinolin-6-amine::US10227343, Example 52

SMILES FC(F)(F)c1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key InChIKey=IMDIQNUECOXRNB-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368520   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368520(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  18nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

US Patent
LigandPNGBDBM368520(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataEC50:  18nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368520(N-(1H-pyrazolo[4,3-b] pyridin-3-yl)-1- (trifluorom...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed