BDBM368549 1-ethyl-N-(1H-pyrazolo [4,3-b]pyridin- 3-yl)isoquinolin- 6-amine::US10227343, Example 81

SMILES CCc1nccc2cc(Nc3n[nH]c4cccnc34)ccc12

InChI Key InChIKey=LWNMUAQSSXQMHE-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 368549   

TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368549(1-ethyl-N-(1H-pyrazolo [4,3-b]pyridin- 3-yl)isoqui...)
Affinity DataEC50:  45nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor/Gqi5 in presence of EC20 glutamate by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368549(1-ethyl-N-(1H-pyrazolo [4,3-b]pyridin- 3-yl)isoqui...)
Affinity DataEC50:  47nMAssay Description:The disclosed compounds and compositions can be evaluated for their ability to act as a potentiator of metabotropic glutamate receptor activity, in p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetCytochrome P450 1A2(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM368549(1-ethyl-N-(1H-pyrazolo [4,3-b]pyridin- 3-yl)isoqui...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed