BDBM368687 US10227350, Compound 102

SMILES Nc1nccc(-c2cc(-c3nnc[nH]3)c3ncn(-c4ccnc5c(F)ccc(F)c45)c3c2)c1F

InChI Key InChIKey=NFMJPNIMDSAFQE-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 368687   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Gilead Sciences

Curated by ChEMBL

LigandBDBM368687(US10227350, Compound 102)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Inhibition of full length human His-tagged p110beta/p85alpha using PIP2 as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Human)
Gilead Sciences

US Patent

LigandBDBM368687(US10227350, Compound 102)Copy SMILESCopy InChI

Affinity DataIC50: 11nMAssay Description:Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
12/27/2019
Entry Details
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Gilead Sciences

Curated by ChEMBL

LigandBDBM368687(US10227350, Compound 102)Copy SMILESCopy InChI

Affinity DataIC50: 67nMAssay Description:Inhibition of full length human p110delta/p85alpha using PIP2 as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Gilead Sciences

Curated by ChEMBL

LigandBDBM368687(US10227350, Compound 102)Copy SMILESCopy InChI

Affinity DataIC50: 233nMAssay Description:Inhibition of full length human p110alpha/p85alpha using PIP2 as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy BDB DOIPubMed
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TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Gilead Sciences

Curated by ChEMBL

LigandBDBM368687(US10227350, Compound 102)Copy SMILESCopy InChI

Affinity DataIC50: 440nMAssay Description:Inhibition of full length human PI3Kgamma using PIP2 as substrate after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/19/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL