BDBM368990 1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(1- piperidyl)propoxy]quinazolin-4- yl]phenyl]methanesulfonamide::US10227357, Compound P-0254::US10227357, Compound P-0258

SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)-c1ccc(NS(C)(=O)=O)cc1F

InChI Key InChIKey=AVVMMAHIJPBRMN-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 368990   

LigandPNGBDBM368990(1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

LigandPNGBDBM368990(1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM368990(1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(...)
Affinity DataKi:  5.50E+3nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM368990(1,1,1-trideuterio-N-[3-fluoro-4-[6- methoxy-7-[3-(...)
Affinity DataKi:  5.50E+3nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent