BDBM369063 N-(4-chlorophenyl)-3-fluoro-4-[6-(4- fluorophenyl)-7H-pyrrolo[2,3- d]pyrimidin-4-yl]benzenesulfonamide::US10227357, Compound P-0327

SMILES Fc1ccc(cc1)-c1cc2c(ncnc2[nH]1)-c1ccc(cc1F)S(=O)(=O)Nc1ccc(Cl)cc1

InChI Key InChIKey=CRBWUHVLSKHWPN-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 369063   

LigandPNGBDBM369063(US10227357, Compound P-0327 | N-(4-chlorophenyl)-3...)
Affinity DataKi:  500nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetMast/stem cell growth factor receptor Kit(Human)
Plexxikon

US Patent
LigandPNGBDBM369063(US10227357, Compound P-0327 | N-(4-chlorophenyl)-3...)
Affinity DataKi:  1.05E+5nMAssay Description:The c-Kit mutant D816V inhibitors were assessed using an engineered BaF3-FL KIT D816V or BaF3-FL KIT V560G/D816V cell line. The BaF3-FL KIT D816V cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent