BDBM370029 (R)-5-Ethyl-2-fluoro-N-(3-methyl-1-(3-methyl-1-(4-(methylsulfonyl)phenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)-1-oxobutan-2-yl)benzamide::US10233182, Example 200

SMILES CCc1ccc(F)c(c1)C(=O)N[C@H](C(C)C)C(=O)N1CCC2(CC1)N(CN(C)C2=O)c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=AISJEVBDBCFJKD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 370029   

TargetAutotaxin(Human)
X-Rx

US Patent
LigandPNGBDBM370029((R)-5-Ethyl-2-fluoro-N-(3-methyl-1-(3-methyl-1-(4-...)
Affinity DataIC50: 500nMAssay Description:The efficacy of the Examples described herein, as inhibitors of ATX are demonstrated and confirmed by pharmacological in vitro assays. The following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent