BDBM370362 US10233189, Example 45::US10233189, Example 48::US11014930, Example 34

SMILES Cc1cc(NC(=O)c2nn(c3ncnc(N)c23)C(C)(C)C)n[nH]1

InChI Key InChIKey=QIBXPQVQBRFRIY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 370362   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370362(US10233189, Example 48 | US10233189, Example 45 | ...)
Affinity DataIC50: 0.210nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370362(US10233189, Example 48 | US10233189, Example 45 | ...)
Affinity DataIC50: 0.290nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/22/2021
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Taiho Pharmaceutical

US Patent
LigandPNGBDBM370362(US10233189, Example 48 | US10233189, Example 45 | ...)
Affinity DataIC50: 0.788nMAssay Description:To measure the inhibitory activity, first, the compounds of the present invention were individually diluted with dimethyl sulfoxide (DMSO) stepwise. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent