BDBM370517 1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl)ethyl)piperidin-1-yl)-2-(pyridin-4- yl)ethanone::US10233190, Example 1437

SMILES OC(CC1c2ccccc2-c2cncn12)C1CCN(CC1)C(=O)Cc1ccncc1

InChI Key InChIKey=ADXRHXZIAQWYPA-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 370517   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370517(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 230nMAssay Description:Inhibition of purified human IDO1 using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370517(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 values for each compound were determined by testing the activity of IDO in a mixture containing 50 mM potassium phosphate buffer at pH 6.5; ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/27/2019
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370517(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataEC50:  1.30E+3nMAssay Description:Inhibition of recombinant human IDO1 expressed in T-REx-293 cells assessed as reduction in kynurenine level measured after 16 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370517(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin) using midazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370517(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370517(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetCytochrome P450 2B6(Human)
Newlink Genetics

Curated by ChEMBL
LigandPNGBDBM370517(1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol- 5-yl...)
Affinity DataIC50: 5.60E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed