BDBM371197 US10239843, Example 304

SMILES CCn1c2ccc(cc2c(=O)n(Cc2cc(C)no2)c1=O)S(=O)(=O)NC1(C)CC1

InChI Key InChIKey=MWUNZTNMRPOPOH-UHFFFAOYSA-N

Data  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 371197   

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM371197(US10239843, Example 304)
Affinity DataEC50:  120nMAssay Description:Inhibition of PARG in human HeLa cells assessed as induction of MMS-induced PAR chains preincubated for 1 hr followed by MMS addition and measured af...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM371197(US10239843, Example 304)
Affinity DataIC50: 329nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM371197(US10239843, Example 304)
Affinity DataEC50:  330nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed