BDBM371392 1-Methyl-N-(1-methylcyclopropyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)methyl]-2,4-dioxo-quinazoline-6-sulfonamide::US10239843, Example 500

SMILES Cc1nnc(Cn2c(=O)n(C)c3ccc(cc3c2=O)S(=O)(=O)NC2(C)CC2)s1

InChI Key InChIKey=NDVMZPHNWJYELF-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 371392   

TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM371392(US10239843, Example 500 | 1-Methyl-N-(1-methylcycl...)
Affinity DataEC50:  470nMAssay Description:Inhibition of human full length PARG using Bt-NAD ribosylated PARP1 substrate after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetPoly(ADP-ribose) glycohydrolase(Human)
University of Manchester

Curated by ChEMBL
LigandPNGBDBM371392(US10239843, Example 500 | 1-Methyl-N-(1-methylcycl...)
Affinity DataIC50: 472nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
US Patent