BDBM372131 (S)- or (R)-8-(1H-indazole-5-carbonyl)-3-(2-oxo-2-(3-(trifluoromethyl)piperazin-1-yl)ethyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one::US10239876, Example 154::US10435407, Example 154

SMILES FC(F)(F)[C@@H]1CN(CCN1)C(=O)CN1CN(c2ccccc2)C2(CCN(CC2)C(=O)c2ccc3[nH]ncc3c2)C1=O

InChI Key InChIKey=GBSOJTHLVSZFNK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 372131   

TargetD(1A) dopamine receptor(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM372131((S)- or (R)-8-(1H-indazole-5-carbonyl)-3-(2-oxo-2-...)
Affinity DataIC50: 46.7nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2019
Entry Details
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TargetEpithelial discoidin domain-containing receptor 1(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM372131((S)- or (R)-8-(1H-indazole-5-carbonyl)-3-(2-oxo-2-...)
Affinity DataIC50: 46.7nMAssay Description:This assay is based on the intracellular domain of the DDR1 protein which contains the kinase active site. The recombinant protein additionally carri...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details
Go to US Patent