BDBM373084 1,3-bis(2- phenylimidazo[1,2- a]pyridin-3-yl)urea::US9896447, Compound 1

SMILES O=C(Nc1c(nc2ccccn12)-c1ccccc1)Nc1c(nc2ccccn12)-c1ccccc1

InChI Key InChIKey=XDWIRDRPSDHKIT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373084   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373084(1,3-bis(2- phenylimidazo[1,2- a]pyridin-3-yl)urea ...)
Affinity DataIC50: 82nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373084(1,3-bis(2- phenylimidazo[1,2- a]pyridin-3-yl)urea ...)
Affinity DataIC50: 82nMAssay Description:Inhibition of recombinant full length human TRKA expressed in U2OS cells using Poly(Glu:Tyr) as substrate after 30 mins by scintillation counting ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed