BDBM373101 1,3-bis[2- (methylsulfanyl)-4- phenylpyrimidin-5- yl]urea::US9896447, Compound 18

SMILES CSc1ncc(NC(=O)Nc2cnc(SC)nc2-c2ccccc2)c(n1)-c1ccccc1

InChI Key InChIKey=VYGUZSRAWVNHBG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 373101   

TargetHigh affinity nerve growth factor receptor(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM373101(1,3-bis[2- (methylsulfanyl)-4- phenylpyrimidin-5- ...)
Affinity DataIC50: 280nMAssay Description:TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells are express TrkA receptor as a fusion with the we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent