BDBM373177 US9896452, Example 37::rac-N-(((5S)-1-(biphenylcarbonyl)-5-fluoropiperidin-2-yl)methyl)quinoline-8-carboxamide

SMILES F[C@H]1CCC(CNC(=O)c2cccc3cccnc23)N(C1)C(=O)c1ccccc1-c1ccccc1

InChI Key InChIKey=SVWRBCQUGLPUCX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373177   

TargetOrexin/Hypocretin receptor type 1(Human)
Eolas Therapeutics

US Patent
LigandPNGBDBM373177(rac-N-(((5S)-1-(biphenylcarbonyl)-5-fluoropiperidi...)
Affinity DataIC50: 1nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Eolas Therapeutics

US Patent
LigandPNGBDBM373177(rac-N-(((5S)-1-(biphenylcarbonyl)-5-fluoropiperidi...)
Affinity DataIC50: 3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent