BDBM373218 US9896452, Example 79::rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyridin-2-yl)oxy)methyl)piperidin-1-yl) (5-(4-fluorophenyl)-2-methylthiazol-4-yl)methanone

SMILES C[C@@H]1CCCN([C@@H]1COc1ccc(cn1)C(F)(F)F)C(=O)c1nc(C)sc1-c1ccc(F)cc1

InChI Key InChIKey=JMPIATXFWNAJIK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373218   

TargetOrexin/Hypocretin receptor type 1(Human)
Eolas Therapeutics

US Patent
LigandPNGBDBM373218(rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyri...)
Affinity DataIC50: 1nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Eolas Therapeutics

US Patent
LigandPNGBDBM373218(rac-((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyri...)
Affinity DataIC50: 1.00E+4nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent