BDBM373473 (2-Fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-3-methyl-2-(((5-(trifluoromethyl)pyrimidin-2-yl)amino)methyl)piperidin-1-yl)methanone::US9896452, Ex. A240

SMILES C[C@@H]1CCCN([C@@H]1CNc1ncc(cn1)C(F)(F)F)C(=O)c1c(F)cccc1-c1ncccn1

InChI Key InChIKey=SUORDRLKFSHXJA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373473   

TargetOrexin/Hypocretin receptor type 1(Human)
Eolas Therapeutics

US Patent
LigandPNGBDBM373473((2-Fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-3-meth...)
Affinity DataIC50: 3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetOrexin receptor type 2(Human)
Eolas Therapeutics

US Patent
LigandPNGBDBM373473((2-Fluoro-6-(pyrimidin-2-yl)phenyl)((2S,3R)-3-meth...)
Affinity DataIC50: 5.00E+3nMAssay Description:Measurement of [Ca2+]i using a FLIPR: CHO-OX1 or CHO-OX2 cells are seeded into black-walled clear-base 384-well plates (Costar) at a density of 20,00...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent