BDBM373546 1-[6-(2,6-Dimethyl-phenoxy)-7-fluoro-4-propylamino-quinazolin-2-yl]-1H-pyrazole-4-carboxylic acid;::US10246442, Example 8::US10975062, Example 8

SMILES CCCNc1nc(nc2cc(F)c(Oc3c(C)cccc3C)cc12)-n1cc(cn1)C(O)=O

InChI Key InChIKey=KVVPWMJLEOZLSJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 373546   

TargetEgl nine homolog 1 [182-426](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM373546(US10246442, Example 8 | 1-[6-(2,6-Dimethyl-phenoxy...)
Affinity DataIC50: 63.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

TargetEgl nine homolog 1 [181-417](Human)
TBA

US Patent
LigandPNGBDBM373546(US10246442, Example 8 | 1-[6-(2,6-Dimethyl-phenoxy...)
Affinity DataIC50: 63.1nMAssay Description:The PHD enzymatic assay was performed in 0.5 ml of reaction mixture containing the following: purified PHD2181-417 polypeptide (3 μg), synthetic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2021
Entry Details
Go to US Patent