BDBM374005 (R)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2-fluoro-5-methyl-N-(thiazol-4-yl)benzenesulfonamide::US10246453, Example 272::US10815229, Example 272

SMILES CN([C@@H]1CCN(Cc2ccccc2)C1)c1cc(F)c(cc1C)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=UCSHINHOAVARGQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 374005   

TargetSodium channel protein type 8 subunit alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM374005(US10246453, Example 272 | (R)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 51nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by automated patch-clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2024
Entry Details
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM374005(US10246453, Example 272 | (R)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 3.77E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM374005(US10246453, Example 272 | (R)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 3.77E+3nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM374005(US10246453, Example 272 | (R)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1.17E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM374005(US10246453, Example 272 | (R)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1.17E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM374005(US10246453, Example 272 | (R)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1.82E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM374005(US10246453, Example 272 | (R)-4-((1-benzylpyrrolid...)
Affinity DataIC50: 1.82E+4nMAssay Description:In general, Trex HEK293 cells were stably transfected with an inducible expression vector containing the full-length cDNA coding for the desired huma...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2021
Entry Details
US Patent