BDBM374627 1-(1-(2,4-Dichlorophenyl)ethyl)-6-(3′-methyl-[1,4′-bipiperidin]-1′-yl)-1H-pyrazolo[3,4-b]pyrazine hydrochloride::US10246462, Example 8

SMILES CC(c1ccc(Cl)cc1Cl)n1ncc2ncc(nc12)N1CCC(C(C)C1)N1CCCCC1

InChI Key InChIKey=UBRBYLAGHGZRBU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 374627   

TargetC-C chemokine receptor type 4(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM374627(US10246462, Example 8 | 1-(1-(2,4-Dichlorophenyl)e...)
Affinity DataIC50: 238nMAssay Description:Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interv...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2021
Entry Details Article
PubMed
TargetC-C chemokine receptor type 4(Human)
Rapt Therapeutics

Curated by ChEMBL
LigandPNGBDBM374627(US10246462, Example 8 | 1-(1-(2,4-Dichlorophenyl)e...)
Affinity DataIC50: 300nMAssay Description:To measure binding of 125I-TARC or 125I-MDC to cells expressing CCR4 (e.g., CEM cells (e.g., ATCC HB-12624)), the 125I-TARC or 125I-MDC is diluted to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent