BDBM374728 11-fluoro-13-(hydroxymethyl)-6,7,13,14- tetrahydro-1,15-ethenopyrazolo[4,3- f][1,4,8,10]benzoxatriazacyclotridecin-4(5H)- one::US10246466, Example 98::US10618912, Example 98

SMILES OCC1Nc2ccn3ncc(C(=O)NCCOc4ccc(F)cc14)c3n2

InChI Key InChIKey=YDZVTFFLKUNUIU-UHFFFAOYSA-N

Data  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 374728   

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(US10246466, Example 98 | 11-fluoro-13-(hydroxymeth...)
Affinity DataKd:  0.740nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(US10246466, Example 98 | 11-fluoro-13-(hydroxymeth...)
Affinity DataKd:  0.740nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(US10246466, Example 98 | 11-fluoro-13-(hydroxymeth...)
Affinity DataKd:  14nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/20/2020
Entry Details
US Patent

TargetALK tyrosine kinase receptor(Human)
Turning Point Therapeutics

US Patent
LigandPNGBDBM374728(US10246466, Example 98 | 11-fluoro-13-(hydroxymeth...)
Affinity DataKd:  14nMAssay Description:Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., A small molecule-kinase interaction...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent