BDBM374760 US10246467, Example I-47::US10919913, # I-47::US20240109913, Example I-47

SMILES OC(=O)c1ccc2c3OC[C@H]4[C@H]([C@H](c5cccc(Cl)c5F)[C@@]5(N4CC4CC4(F)F)C(=O)Nc4cc(Cl)ccc54)n3nc2c1

InChI Key InChIKey=RLUCXXWXLKLQLP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 374760   

TargetCellular tumor antigen p53 [16-27]/E3 ubiquitin-protein ligase Mdm2 [23-117](Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374760(US10246467, Example I-47 | US10919913, # I-47 | US...)
Affinity DataIC50: 19nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374760(US10246467, Example I-47 | US10919913, # I-47 | US...)
Affinity DataIC50: 19nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2021
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM374760(US10246467, Example I-47 | US10919913, # I-47 | US...)
Affinity DataIC50: 19nMAssay Description:This assay is used to determine whether the compounds inhibit the p53-MDM2 interaction and thus restore p53 function.15 μL of compound in 20% DM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2024
Entry Details
US Patent