BDBM375161 6-{[1-(6-chloro-7-fluoro-2-::US10253015, Compound I-21

SMILES CC(Nc1ccc(C#N)c(C)n1)c1cc2cc(Cl)c(F)cc2[nH]c1=O

InChI Key InChIKey=ZDLSZHBGHIPTJF-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 375161   

LigandPNGBDBM375161(6-{[1-(6-chloro-7-fluoro-2- | US10253015, Compound...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM375161(6-{[1-(6-chloro-7-fluoro-2- | US10253015, Compound...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM375161(6-{[1-(6-chloro-7-fluoro-2- | US10253015, Compound...)
Affinity DataIC50: 550nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM375161(6-{[1-(6-chloro-7-fluoro-2- | US10253015, Compound...)
Affinity DataIC50: 550nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent