BDBM375207 6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3-::US10253015, Compound I-67

SMILES Clc1ccc2[nH]c(=O)c(CNc3ccc(cn3)C#N)cc2c1

InChI Key InChIKey=GWBZGQRLLUJXRH-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 375207   

LigandPNGBDBM375207(6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3- | US102...)
Affinity DataIC50: 55nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Forma Therapeutics

Curated by ChEMBL
LigandPNGBDBM375207(6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3- | US102...)
Affinity DataIC50: 365nMAssay Description:Inhibition of human Myc-DDK-tagged IDH1 R132H mutant assessed as reduction in NADPH consumption pre-incubated for 15 mins followed by alpha-ketogluta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM375207(6-{[(6-chloro-2-oxo-1,2-dihydroquinolin-3- | US102...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent