BDBM375223 6-{[(6-chloro-7-methoxy-2-oxo-1,2-::US10253015, Compound I-83

SMILES COc1cc2[nH]c(=O)c(CNc3ccc(C#N)c(C)n3)cc2cc1Cl

InChI Key InChIKey=JKVBPFJAMHQRCZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 375223   

LigandPNGBDBM375223(6-{[(6-chloro-7-methoxy-2-oxo-1,2- | US10253015, C...)
Affinity DataIC50: 10nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM375223(6-{[(6-chloro-7-methoxy-2-oxo-1,2- | US10253015, C...)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays were performed in a 384-well black plate. An aliquot of 250 nL of compound was incubated with 10 μL of 30 nM IDH1-R132H or 10 nM IDH1-R13...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM375223(6-{[(6-chloro-7-methoxy-2-oxo-1,2- | US10253015, C...)
Affinity DataIC50: 1.00E+3nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM375223(6-{[(6-chloro-7-methoxy-2-oxo-1,2- | US10253015, C...)
Affinity DataIC50: 1.00E+3nMAssay Description:HCT116 isogenic IDH1-R132H and IDH1-R132C mutant cells were cultured in growth media (McCoy's 5 A, 10% fetal bovine serum, 1× antibiotic-antimyco...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/21/2020
Entry Details
Go to US Patent