BDBM375401 US9907800, Example A117

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(nc3)N3CCC(O)CC3)c2c1

InChI Key InChIKey=UOUWRLIIMOCVBC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 375401   

TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM375401(US9907800, Example A117)
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PLK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM375401(US9907800, Example A117)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM375401(US9907800, Example A117)
Affinity DataIC50: 240nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetAurora kinase B(Human)
University Health Network

US Patent
LigandPNGBDBM375401(US9907800, Example A117)
Affinity DataIC50: 550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent