BDBM375412 US10358436, Example A124::US9907800, Example A124

SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(n[nH]c4c3)-c3ccc(cc3)C3(F)CCN(C)CC3)c2c1

InChI Key InChIKey=MRRJIJBPTGTPLV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 375412   

TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM375412(US9907800, Example A124 | US10358436, Example A124)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PLK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM375412(US9907800, Example A124 | US10358436, Example A124)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM375412(US9907800, Example A124 | US10358436, Example A124)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM375412(US9907800, Example A124 | US10358436, Example A124)
Affinity DataIC50: 200nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed