BDBM375828 US9914731, Ex. No. 50

SMILES Cc1ccc(C(=O)Nc2ccc(Oc3cc(cn4nccc34)C3CCS(=O)(=O)CC3)c(F)c2)c(=O)n1-c1ccc(F)cc1

InChI Key InChIKey=ROIQIHDYHIULRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 375828   

TargetHepatocyte growth factor receptor(Human)
Ignyta

US Patent
LigandPNGBDBM375828(US9914731, Ex. No. 50)
Affinity DataIC50: 10nMAssay Description:The cMET kinase assay was performed in 384-well Fluotrac 200 HiBase microplates using the HTRF KinEASE assay described above for AXL except that the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent

TargetTyrosine-protein kinase receptor UFO(Human)
Ignyta

US Patent
LigandPNGBDBM375828(US9914731, Ex. No. 50)
Affinity DataIC50: 55nMAssay Description:The ability of compounds to inhibit the kinase activity of recombinant human baculovirus-expressed AXL was measured by homogeneous TRF (HTRF) using C...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/30/2020
Entry Details
US Patent