BDBM377195 5-Amino-N-{4-[(3S,5R)-3-amino-5-(trifluoromethyl)piperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamide::US10265307, Example 44-1::US10517858, Example 44 (Diastereoisomer 1)::US10828290, Example 44 (Diastereoisomer 1)::US11229631, Example 44 Diastereoisomer 1

SMILES N[C@H]1C[C@H](CN(C1)c1c2CC[C@H](O)c2ncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F)C(F)(F)F

InChI Key InChIKey=ORPHXBGOTIFKKC-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 377195   

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays—20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μcompound/DMSO in the assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/28/2021
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-2 kinase assay-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay buffer (50 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-3(Human)
Incyte

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.84 compound/DMSO in the assay buffer (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Incyte Holdings

US Patent
LigandPNGBDBM377195(US10265307, Example 44-1 | 5-Amino-N-{4-[(3S,5R)-3...)
Affinity DataIC50: 100nMAssay Description:Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2022
Entry Details
US Patent