BDBM377694 US10266496, Example 6

SMILES Cn1c(cc2c(cc(cc12)C#N)-c1ccc(C(O)=O)c(O)c1)C(F)(F)F

InChI Key InChIKey=OUFFVASKHWVJMU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 377694   

TargetXanthine dehydrogenase/oxidase(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377694(US10266496, Example 6)
Affinity DataIC50: 66.2nMAssay Description:The compound was diluted 2.5 fold with a buffer of 50 mM KH2PO4 to give a series of concentrations from 2000 nM to 0.524 nM. Then the diluted solutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetSolute carrier family 22 member 12(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM377694(US10266496, Example 6)
Affinity DataIC50: 234nMAssay Description:a. Construction of a Cell Line Stably Expressing hURAT1hURAT1 plasmid was transfected into HEK293T cell, and a cell line stably expressing hURAT1 was...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent