BDBM378893 5,8-dichloro-2-((7-methyl-5-oxo-5,6-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)methyl)-7-(7-oxa-2-azaspiro[3.5]nonan-2-yl)-3,4-dihydroisoquinolin-1(2H)-one::US10266542, Example 5

SMILES Cc1[nH]c(=O)c(CN2CCc3c(Cl)cc(N4CC5(C4)CCOCC5)c(Cl)c3C2=O)c2CCNc12

InChI Key InChIKey=CLHMBIIGBFZQOV-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 378893   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378893(US10266542, Example 5 | 5,8-dichloro-2-((7-methyl-...)
Affinity DataIC50: 0.5nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent