BDBM378905 5,8-dichloro-7-(methoxy(1-methylazetidin-3-yl)methyl)-2-((7-methyl-5-oxo-5,6-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one::US10266542, Example 11::US10266542, Example 12

SMILES COC(C1CN(C)C1)c1cc(Cl)c2CCN(Cc3c4cc[nH]c4c(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=GPJXXWVIWSOVQN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 378905   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378905(US10266542, Example 11 | US10266542, Example 12 | ...)
Affinity DataIC50: 10nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Mirati Therapeutics

US Patent
LigandPNGBDBM378905(US10266542, Example 11 | US10266542, Example 12 | ...)
Affinity DataIC50: 37nMAssay Description:Ten-point dose-response curves for a subset of compounds shown in Table 1 were determined using a Transcreener EPIGEN Methyltransferase HTS assay usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2020
Entry Details
US Patent