BDBM379839 US9926281, Compound 269::US9926281, Compound 446

SMILES CC(CC1(NC(=O)NC1=O)c1ccccn1)C(=O)N1CCN([C@@H](C)C1)c1cccc(Cl)c1

InChI Key InChIKey=ARVDGBFKIFLARF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 379839   

LigandPNGBDBM379839(US9926281, Compound 269 | US9926281, Compound 446)
Affinity DataIC50: 19nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

LigandPNGBDBM379839(US9926281, Compound 269 | US9926281, Compound 446)
Affinity DataIC50: 19nMAssay Description:ADAMTS-5:Protocol 2: The basis for the assay is the cleavage of the substrate TBIS-1 (5 FAM-TEGEARGSVILLK (5TAMRA)K-NH2) (SEQ ID No 2) by human ADAMT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379839(US9926281, Compound 269 | US9926281, Compound 446)
Affinity DataIC50: 119nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

LigandPNGBDBM379839(US9926281, Compound 269 | US9926281, Compound 446)
Affinity DataIC50: 840nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

LigandPNGBDBM379839(US9926281, Compound 269 | US9926281, Compound 446)
Affinity DataIC50: 840nMAssay Description:TACE:The basis for the assay is the cleavage of the substrate 5FAM-LAQAVRSSSRK-5TAMRA (SEQ ID No 3) (Anaspec, custom 34891) by human TACE (R&D SYSTEM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent

Target72 kDa type IV collagenase(Human)
Galapagos

US Patent
LigandPNGBDBM379839(US9926281, Compound 269 | US9926281, Compound 446)
Affinity DataIC50: 2.00E+4nMAssay Description:MMP2: Protocol 2: The basis for the assay is the cleavage of the substrate 390 MMP FRET substrate I (Anaspec, Catalog n#: AS-27076) by human MMP2 (R&...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent