BDBM38021 US10093646, Compound 2::US10301278, Example 00004::US10336774, Example 02::US10774065, Example 00004::US11401259, Compound 2

SMILES CC1(N)CCN(CC1)c1cnc(cn1)-c1cccc(Cl)c1Cl

InChI Key InChIKey=YJISKINOWNRRNX-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 38021   

LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50: 5.70E+3nMpH: 7.2 T: 2°CAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/22/2019
Entry Details
Go to US Patent

LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50: 5.70E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2020
Entry Details
Go to US Patent

LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50: 5.70E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50: 5.70E+3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human 6his-tagged SHP2 (2 to 593 residues) expressed in Escherichia coli BL21 Star (DE3) cells preincubated with IRS1_pY1172(dPEG8)pY12...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50: 5.70E+3nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/25/2022
Entry Details Article
PubMed
LigandPNGBDBM38021(US10093646, Compound 2 | US10301278, Example 00004...)
Affinity DataIC50: 5.70E+3nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
Go to US Patent