BDBM380568 US9926330, 2-21::trans-N-[(1S)-1- cyclopropylethyl]-N'-(6- methylquinazolin-4- yl)cyclohexane-1,4- diamine

SMILES CC(N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12)C1CC1

InChI Key InChIKey=VOJNVEXMZRWJHK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 380568   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM380568(trans-N-[(1S)-1- cyclopropylethyl]-N'-(6- methylqu...)
Affinity DataIC50: 73nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent