BDBM380569 US9926330, 2-22::trans-N-(6- methylquinazolin-4-yl)-N'- [(1S)-3,3,3-trifluoro-1- methylpropyl]cyclohexane- 1,4-diamine

SMILES CC(CC(F)(F)F)N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12

InChI Key InChIKey=JIXZRQNDUSFXGA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 380569   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM380569(US9926330, 2-22 | trans-N-(6- methylquinazolin-4-y...)
Affinity DataIC50: 67nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent