BDBM380578 US9926330, 2-31::trans-N-[(1S)-1-methyl-2- (methylsulfonyl)ethyl]-N'- (6-methylquinazolin-4- yl)cyclohexane-1,4- diamine

SMILES CC(CS(C)=O)N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12

InChI Key InChIKey=VMXHQFGDIILERB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 380578   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM380578(US9926330, 2-31 | trans-N-[(1S)-1-methyl-2- (methy...)
Affinity DataIC50: 56nMAssay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2020
Entry Details
US Patent