BDBM380818 8-Quinolin-6-yl-3,4-dihydro-1H- pyrano[4,3-c]pyridin-4-ol, Enantiomer I::US9890171, 22::US9890171, 35

SMILES OC1COCc2c1cncc2-c1ccc2ncccc2c1

InChI Key InChIKey=ACBJGCQANFUUBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380818   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380818(US9890171, 35 | 8-Quinolin-6-yl-3,4-dihydro-1H- py...)
Affinity DataIC50: 64.1nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380818(US9890171, 35 | 8-Quinolin-6-yl-3,4-dihydro-1H- py...)
Affinity DataIC50: 9.70nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent