BDBM380824 8-(3,4-Dihydro-2H- benzo[b][1,4]dioxepin-7-yl)-3,4- dihydro-1H-pyrano[4,3-c]pyridin-4- ol, Enantiomer I::US9890171, 28::US9890171, 43

SMILES OC1COCc2c1cncc2-c1ccc2OCCCOc2c1

InChI Key InChIKey=FJAIICOJZGATOP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380824   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380824(8-(3,4-Dihydro-2H- benzo[b][1,4]dioxepin-7-yl)-3,4...)
Affinity DataIC50: 333nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380824(8-(3,4-Dihydro-2H- benzo[b][1,4]dioxepin-7-yl)-3,4...)
Affinity DataIC50: 22nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent