BDBM380913 6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-8-yl)-3,4- dihydro-2H-naphthalen-1-one, Enantiomer I::US9890171, 117::US9890171, 118

SMILES OC1COCc2c1cncc2-c1ccc2C(=O)CCCc2c1

InChI Key InChIKey=IKHCJSFCEKLZPL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 380913   

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380913(6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 103nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent

TargetCytochrome P450 11B2, mitochondrial(Human)
Boehringer Ingelheim International

US Patent
LigandPNGBDBM380913(6-(4-Hydroxy-3,4-dihydro-1H- pyrano[4,3-c]pyridin-...)
Affinity DataIC50: 12.5nMAssay Description:The aldosterone synthase inhibition assay employs cynomolgus adrenal gland mitochondria as the source of aldosterone synthase (CYP11B2). Mitochondria...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/16/2020
Entry Details
Go to US Patent