BDBM381071 1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxyphenyl)-3-(4-((2-((pyridin-2-ylmethyl)-amino)pyrimidin-4-yl)oxy)naphthalen-1-yl)urea::US9890185, Example 32

SMILES COc1c(NC(=O)Nc2ccc(Oc3ccnc(NCc4ccccn4)n3)c3ccccc23)cc(cc1P(C)(C)=O)C(C)(C)C

InChI Key InChIKey=PJUSCKOQLSMBPU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 381071   

TargetMitogen-activated protein kinase 14(Human)
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US Patent
LigandPNGBDBM381071(1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxy...)
Affinity DataIC50: 6nMAssay Description:Method 1: The inhibitory activities of test compounds against the p38 MAPKα isoform (MAPK14: Invitrogen), are evaluated indirectly by determinin...More data for this Ligand-Target Pair
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Date in BDB:
2/16/2020
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent
LigandPNGBDBM381071(1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxy...)
Affinity DataIC50: 1.11E+3nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair
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Date in BDB:
2/16/2020
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TargetTyrosine-protein kinase SYK(Human)
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LigandPNGBDBM381071(1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxy...)
Affinity DataIC50: 1.60E+3nMAssay Description:Method 2: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to t...More data for this Ligand-Target Pair
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Date in BDB:
2/16/2020
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent
LigandPNGBDBM381071(1-(5-(tert-Butyl)-3-(dimethylphosphoryl)-2-methoxy...)
Affinity DataIC50: 988nMAssay Description:Method 1: The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining t...More data for this Ligand-Target Pair
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Date in BDB:
2/16/2020
Entry Details
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